ABSTRACT
The review considers the role that selenium plays in RNA virus infections and, in particular, COVID-19. Many RNA viruses are selenium dependent because antisense interactions arise between viral RNAs and host mRNA regions containing the selencysteine insertion sequence to cause selenium deficiency, oxidative stress, immune response impairment, etc. Sodium selenite is a licensed selenium-containing product and is widely used in medicine, veterinary, and agriculture. Its advantages include the following. Sodium selenite rapidly penetrates through cell membranes in all tissues of the body; is intensely involved in metabolic processes accompanied by oxidation of sulfur-containing cell proteins; exerts an antiaggregation effect by reducing thromboxane activity; interrupts the contact of a virion (SARS-CoV-1 and SARS-CoV-2) with the membrane of a healthy cell; and suppresses NF-κB activity, which significantly increases in coronavirus infections. Arguments supporting the use of sodium selenite as adjuvant therapy in COVID-19 are discussed.
ABSTRACT
Visually impaired people are often associated with various complex problems because they are considered unproductive even for daily health, so that daily health literacy is needed. The most needed aspects for visually impaired people are balanced nutrition, covid-19, and information on the nearest health service. The location of the difference in health literacy between people who see and people with visual impairment is accessibility. The purpose of this study is to describe the Participation Action Research (PAR) Protocol on Daily Health Literacy Using Voice Recognition Applications for visually impaired people in Indonesia. We will conduct a study using the Mixed Exploratory method, which is a method that in the early stages of research uses qualitative methods and the next stage uses quantitative methods. The mixing of the data of the two methods is connecting between the results of the first and subsequent studies. This exploratory type is a sequential model (sequence). The research stages are divided into three starting from pre-intervention by conducting systematic reviews, preliminary studies, and qualitative studies, as well as application design, the second stage is intervention through two groups, namely, the intervention group carried out health literacy using voice recognition applications and the control group carried out intervention using e-mail.-book reader, the intervention is continued with assistance for the blind by partners for 30 days, the third stage is post-intervention by monitoring and evaluating behavior, and evaluating applications for evolution and publication of applications to the play store for use by visually impaired people in Indonesia.
ABSTRACT
We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift in the electrolyte balance of blood plasma were revealed in all studied groups and were most pronounced in patients with cardiovascular pathologies with allergy to statin. It was found that low pH promotes destruction of lipid components of the erythrocyte membranes in patients with chronic pathologies, which was seen from a decrease in Na+/K+-ATPase activity and significant hyponatrenemia. In patients with cardiovascular pathologies and allergy to statins, erythrocyte membranes were most sensitive to a decrease in pH, while erythrocyte membranes of obese patients showed the greatest resistance to low pH and oxidative stress.